The coronavirus disease, or COVID-19, is still causing havoc in the Philippines, making it one of the worst-affected countries in Asia. However, even prior to the global health crisis, pharmacists performed a vital role in patient care. In accordance with this, Bragazzi et al. (2020) reiterated that hospital pharmacists moved into new responsibilities and played a vital role during the COVID-19 pandemic. As a result, the purpose of this study is to identify the responsibilities of hospital pharmacists and compare them before and during the COVID-19 pandemic. The research only looked at two of the most important functions of hospital pharmacists in the Philippines: dispensing and patient and medication counseling. Furthermore, it was carried out in fourteen (14) participating Level 3 Department of Health (DOH) general and specialty hospitals in Metro Manila, employing a quantitative, cross-sectional, non-experimental design. To summarize the data, descriptive statistics, especially mean and standard deviation, were employed. Meanwhile, to compare the perceived barriers to pharmaceutical care implementation before and during the COVID-19 pandemic, the mean scores for each category of barriers were subjected to t-test independent. In addition, the weighted score for each category was ranked. The study revealed that there is a significant difference in perceived barriers to pharmaceutical care implementation before and during the COVID-19 pandemic, implying that the role of hospital pharmacists is considerably challenged during the global health crisis.