Beatriz Rodrigues Pellegrina Soares,Institute of Tropical Medicine, Brazil
Title: Incidence of cancers, Risk Factors, and Survival in HIV-infected patients in Brazil, 1989-2020 cohort study
This study aimed to report cancer incidence and mortality in a Brazilian HIV cohort of 31 years duration. We also investigated risk factors for the development of AIDS-defining and non-AIDS-defining cancers. Methods: We searched for any information related to the diagnosis of cancer, electronic records, from our cohort spanning a period ranging from 1989 to 2020. We also collected data on the lowest and current CD4 + cell counts, highest and current HIV viral load, and risk factors for cancer and the causes of death. Statistical analysis included parametric and non-parametric tests, as well as the building of survival curves. We used the statistical software STATA (version 14). Results: Fifty-five new cases of cancer occurred in 677 HIV patients included in our cohort over 31 years, an incidence of 8.12%. We identified cases of AIDS-defining neoplasms presented (n=15;27.27%); while nonAIDS-defining neoplasms (n=40;72.73%). We identified the most relevant risk factors for the study, such as smoking status (n=21;39.60%; p=0.028) and oncogenic HPV (n=16;29.10%; p<0.001) and HCV infection (n=6;9.10%; p=0.034) and nadir <350 cells/mm³ (n=45;81.82%) vs ?350 (n=10;18.18%; p=0.039). A total of 35 cases died, and eleven (1.6%) patients died from cancer, and their mean follow-up time was 14 years. Patients dying from non-cancer causes were 24 (3.55%), and their mean follow-up time was 11 years. Conclusions: Finally, smoking status, HPV, and HCV were the risk factors more strongly associated with cancers in this study. Demonstrates the importance of HPV vaccination for PLHIV and implantation of prevention strategies and inclusion of anal neoplasm (CID-10 C21) by HPV infection should be important to define as an AIDS event as has been done in cervical/uterine in women. Therefore, additional studies would be assessed to include HPV as an AIDS event among PLHIV in a long fashion
Beatriz Rodrigues Pellegrina Soares has completed her Master’s degree from the Institute of Tropical Medicine – FMUSP (2022), São Paulo. She is pharmaceuticals for 7 years. She is a volunteer Member of the Hospital Pharmacy Technical Working Group of the Conselho Regional de Farmácia of State São Paulo (2017- at present). She is a postgraduate in Clinical Pharmacy in Infectology from Braz Cubas (2020), Hospital Pharmacy - Introduction to Clinical Pharmacy from FMUSP (2018), and Regulatory Affairs in the Pharmaceutical Industry from ICTQ (2018). Scientific Initiation Student from UNICSUL (2012-2013). Research Highlights in Health and Biological Sciences from FMUSP (2021). She has published two scientific articles, participated in Nacional Congresses as a moderator and poster and video presentations, published a chapter of the book Human Immunodeficiency virus (HIV) infection 31 years of experience in outpatient care (2021) and participated in an interview about New Therapies for HIV in the CRF-SP pharmacist magazine (2020).