Habibur RahmanPSG College of Pharmacy, India
Title: Development of solid lipid nanoparticles for improved oral bioavailability of tetrahydrocurcumin in rats
Background and objectives: Although tetrahydrocurcumin (THC) possess several pharmacological properties, its clinical application is hindered by its poor oral bioavailability. To test whether the delivery as solid lipid nanoparticles (SLNs) could improve the oral bioavailability of THC, the present study was conducted.
Methods: Several batches of THC loaded SLNs (TS) were prepared using two different lipid carriers (Sterotex HM and stearic acid), five stabilizers (polyvinyl pyrrolidine, propylene glycol, poloxamer 188, PEG 400 and PEG 6000) and a surfactant (tween 80). TS formulations were characterized for size, zeta potential, morphology, entrapment efficiency, physical state of the drug, and in vitro drug release profile of SLNs. Pharmacokinetic studies were conducted in male Wistar rats using selected TS formulations.
Results: The particle size of the SLNs was within the range of 25.4 ± 3.2 and 148.2 ± 2.8 nm across various TS formulations. Pharmacokinetic studies have revealed that the delivery of THC as SLNs enhanced the amount of drug reaching the systemic circulation of Wistar rats.
Conclusion: Delivery as SLNs enhanced the oral bioavailability of THC.
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