Virtual Conference
Pharma Conference 2022

Hasyrul Hamzah

Univeritas Muhammdiyah Kalimantan Timur, Indonesia

Title: Tracing the activity of polymicrobial antibiofilm on catheters from the ethanol extract of bajakah tampala (Spatholobus littoralis Hassk) Typical Plants of the Island of Borneo

Abstract

Biofilm growth on catheters is associated with urinary tract nosocomial infections and causes an increase in mortality every year worldwide. Urinary catheters are a significant factor in CAUTI, with 70 to 80% of infections currently attributable to biofilms. Bajakah Tampala is a native plant of Kalimantan, which has antibacterial activity, but no one has reported its antibiofilm activity so far. The effectiveness of the Bajakah Tampala antibiofilm against polymicrobial biofilms was analyzed by calculating the minimum biofilm inhibitor concentration (MBIC50) and the minimum biofilm eradication concentration (MBEC50). The mechanism of action of biofilm inhibition was evaluated using scanning electron microscopy (SEM). Flavonoid compounds, alkaloids, and terpenoids are nanomaterials that play an important role in Bajakah Tampala, where the ethanol extract of Bajakah Tampala has antibacterial and antifungal activity. The ethanol extract of Bajakah Tampala also had antibiofilm activity against mono-species S. aureus, E. coli, and C. albicans in the middle phase (24 hours). It exerted activity against polymicrobial biofilms on the catheter in the middle (24 h) and maturation phases (48 h). The results also provide evidence that Bajakah Tampala ethanol extract can eradicate polymicrobial biofilms on catheters. Therefore, Bajakah Tampala has the potential to be developed as a candidate for new antibiofilm agents against polymicrobial biofilms on catheters.

Biography

Hasyrul Hamzah has completed his PhD at the age of 26 from the Faculty of Pharmacy, Gadjah Mada University, Indonesia. He focuses on Biofilm research: the search for new candidate antibiofilm compounds from plants in Indonesia.  He is the dean of the Faculty of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Indonesia. He has various publications published in International and National journals. He has served as a member of the editorial boards of several journals in Indonesia and has been on a team of reviewers for reputable national and international journals.