Virtual Conference
Pharma Conference 2022

Isupova A.A

Kyrgyz Russian Slavic University, Kyrgyzstan

Title: Frequency of reference values and determinants of serum 25(oh) d indicators of indigenous people of Kyrgyzstan

Abstract

The work for the first time describes for the first time the level and determinants of fluctuations in the average levels of serum 25(OH)D among the indigenous people of Kyrgyzstan.

Relevance:
Vitamin D is currently receiving increasing attention. 25(OH)D deficiency contributes to the development of both skeletal (rickets, osteopenia, osteoporosis) and non-skeletal pathological effects (dermatosis, hypertension, obesity, oncological, endocrine, autoimmune and infectious diseases). A serum 25-hydroxyvitamin D level of >75 nmol/L, or 30 ng/mL, is essential to maintain human health.

The purpose of the study:
to find out whether gender and seasonal fluctuations in the level of UVR are determinants of vitamin 25(OH)D deficiency among healthy indigenous people of Kyrgyzstan.

Material and methods:
A pilot multicenter cross-sectional study of the level of serum 25(OH)D in the indigenous population of Kyrgyzstan (41°N, 75°E; duration of sunshine 1700-2900 hours/year) was carried out.

Results:
The sample is represented by 293 healthy indigenous people from various regions of Kyrgyzstan. 129 (44.0%) men and 164 (56.0%) women were examined. The mean age of the representative sample was 38.7±0.9 (95% CI 36.0-40.5) years. The age range is from 17 to 77 years, represented by five age groups. The exclusion group included 62 (17.2%) people. The average level of 25(OH)D in the blood serum of the examined was 38.7±1.0 (95% CI 36.6-40.7) nmol/l, there were no statistically significant gender differences (p=0.066). Seasonal fluctuations were revealed — from 30.2±1.9 (95% CI 26.3-34.1) nmol/l in winter to 46.6±1.9 (95% CI 42.8-50.3) nmol/l l in autumn (p=0.0001). The level is less than 50 nmol/l in 71.3±2.6 (95% CI 66.1-76.5)% of cases, 50-75 nmol/l in 24.6±2.5 (95% CI 19.7-24.5)% of cases; more than 75 nmol/l — in 4.1±1.2 (95% CI 1.8-6.4)% of cases.

Conclusions:
The study showed a deficiency in the level of 25-hydroxyvitamin D in the blood serum of more than 70% of healthy native residents of Kyrgyzstan. The findings provide the basis for an expanded study to identify the determinants of vitamin D deficiency.

Biography

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