Karlina Amir TahirUIN Alauddin Makassar, Indonesia
Title: Collagen thickness and density in BALB/c mice exposed to UVB light after using siam weeds cream (Chromolaena odorata L.)
Exposure to ultraviolet B (UVB) rays can cause damage to the skin's dermis layer, one of which causes collagen fragmentation. Damage to collagen causes aging, which is characterized by wrinkles. This study aimed to determine the effect of Siam Weeds cream (Chromolaena odorata L.), which was formulated in cream dosage form, on the thickness and density of collagen in the skin of BALB/c mice after exposure to UVB. 24 BALB/c mice were divided into four groups, namely the normal control group, negative control group, positive control group (UVB), and the treatment group. The Siam Weeds cream formulation with a concentration of 1% was applied just before and after the mice were exposed to UVB at 500 mJ/cm2. A back skin excisional biopsy was conducted to analyze collagen. The treatment group differed significantly both in thickness and density of collagen against the positive control group and the negative control group (p<0.05) and there was no significant difference between the normal group (p>0.05). C. odorata cream with a concentration of 1% can increase the thickness and density of collagen.
Karlina Amir Tahir has completed her PHD at the age of 35 years from Universitas Hasanuddin, Makassar, Indonesia. She is a lecturer of Department of Pharmacy, Faculty of Medicine and Health Science, Indonesia. She has over 15 publications that have been cited over 15 times, and her publication h-index is 2.