Virtual Conference
Pharma Conference 2022

Liudmyla Denyshchych

National Pirogov Memorial Medical University, Ukraine

Title: Serum levels of osteocalcin and C-terminal telopeptide of type I collagen in women with systemic lupus erythematosus, their relationship with bone mineral density and disease activity

Abstract

It is known that patients with systemic lupus erythematosus (SLE) have a lower bone mineral density (BMD) compared to healthy individuals. A significant role in bone loss is played by disorders of bone metabolism due to the activity of SLE with hypercytokinemia. The aim of our study was to examine the levels of osteocalcin and C-terminal telopeptide of type I collagen (CTX) in SLE women, to evaluate their relationship with BMD and disease activity. 58 SLE women and 29 individuals from the control group were examined. Disease activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Serum levels of osteocalcin, CTX and IL-6 were studied by enzyme immunoassay. Lumbar and hip BMD was determined by dual-energy X-ray absorptiometry. It was found that in SLE patients the average osteocalcin level was 20.9% lower and CTX level was 42.0% higher than in healthy individuals. In the group of patients with SLEDAI ? 20 points CTX level was 22.7% significantly higher compared to persons with SLEDAI < 20 points. No significant changes in osteocalcin content were observed between these groups. 

However, there was a significant association between accelerated bone resorption and suppressed bone formation and the high level of IL-6. BMD in the group of patients with altered bone metabolism was 13.7-19.3% lower than in individuals without changes in bone turnover markers. Thus, in SLE patients there is a violation of bone remodeling in the form of accelerated bone resorption and suppressed bone formation. Bone metabolic imbalance was closely associated with decrease of BMD and high disease activity.

Biography

Liudmyla Denyshchych has completed her PHD at the age of 29 years from National Pirogov Memorial Medical University, Vinnytsya, Ukraine. She is an Assistant Professor at the Department of Internal Medicine at National Pirogov Memorial Medical University, Vinnytsya, Ukraine. She has over 17 publications. She has been serving as an reviewer of several Scopus journals.