Virtual Conference
Pharma Conference 2022

Nikhil Sutar

PES University, India

Title: Effect of carboxmethyl chitosan on budesonide ileo colon targeting compression coated tablets

Abstract

Chitosan and its derivatives are used extensively as polymers in drug delivery formulations mainly because of their biocompatibility and low toxicity. Carboxmethyl chitosan (CMCH) was synthesized and its formation was confirmed by proton NMR, FTIR. The modified form of chitosan was indispensable in targeting and utilizing its colon release properties when incorporated in the formulation for the treatment in inflammatory bowel disease (IBD). Compression coating has been found to be much valued for colonic drug delivery. The objective of the present investigation was to design a formulation with a considerably reduced coat weight and chitosan concentration for ileo-colonic delivery of budesonide for the treatment of IBD. The colon responsive matrix tablets were prepared by wet granulation and compression coated with Eudragit S100: HPMC K100M in different ratios to prevent drug release in acidic medium. The optimized formulation (F1C3) exhibited less than 10% drug release in pH 1.2 and a rapid release upon pH change to 6.8 for more than 11 hours. Evidence showed that the compression coated CMCH matrix tablets exhibit pH specific re-lease profile. The optimized formulation F1C3 was then subjected to in-vitro release kinetics with enzymes. The presence of pepsin in pH 1.2, diastase, and pancreatin in pH 6.8 did not have any significant effect in release kinetics of the matrix tab-lets. However, upon addition of the colonic enzymes in the tenth hour, there was significant increase in release of budesonide. Thus, the ileo-colon site specific release by the compression coated CMCH matrix tablets was confirmed.

Biography

Nikhil Sutar has completed his M. Pharm from Rajiv Gandhi University of Health Sciences, Bengaluru, India. He is a full-time PhD research scholar, Faculty of Pharmaceutical Sciences, PES University, Bengaluru. Dr. Satish C. S. has completed his PhD from Rajiv Gandhi University of Health Sciences, Bengaluru, India. He is currently working as Chairperson Department of Pharmaceutics, PES University. Dr. Satish C. S. has published more than 25 abstracts in different journals.