Virtual Conference
Pharma Conference 2022

Raju Asirvatham

St. Joseph’s College of Pharmacy, India

Title: Neuroprotective effects of hydroalcoholic extract of Adhatoda beddomi on omeprazole induced dementia in experimental rats

Abstract

Omeprazole is the most commonly used proton pump inhibitor (PPI), a prospective cohort study reported that chronic use of PPIs causes dementia. The present study aimed to evaluate the protective effect of hydroalcoholic extract of Adhatoda beddomi (HAEAB) on omeprazole induced dementia in experimental rats.  A total of 42 trained rats were divided into 7 groups, each group with six rats. The first group received normal food and water for 21 days. Second, third and fourth group animals were treated with 20 mg/kg of omeprazole for 7, 14, and 21 days respectively. Fifth, sixth and seventh groups of animals received 100 mg/kg of HAEAB + 20 mg/kg of omeprazole for 7, 14, and 21 days respectively. Behavioral studies were conducted on the 0th, 7th, 14th, and 21st days of treatment by using an actophotometer, elevated plus maze (EPM) and cook's pole climbing apparatus. On the next day of the behavior study, respective group animals were sacrificed, and the brain was isolated for estimation of antioxidants, neurotransmitters, and histopathological studies. Locomotor activity, the number of entry into open arms and time were taken to climb the poles were significantly reduced in 20 mg/kg of omeprazole treated rats whereas activity, learning, and memory were restored in 100 mg/kg of HAEAB treated rats concerning the duration of exposure. Alteration of antioxidant enzyme, neurotransmitter level and histopathological events were found in disease control rats which were also corrected by the administration of 100 mg/kg of HAEAB. Co-administration of A.beddomi hydroalcoholic extract diminishes the progress of dementia caused by omeprazole and may be a potential cornerstone in the treatment strategies for researchers and clinicians.

Biography

Raju A has completed his PHD at the age of 38 years from Jawaharlal Nehru Technological University Hyderabad – Thelugana, India. He is working as a Professor in department of Pharmacology, St. Joseph’s College of Pharmacy, Cherthala, Kerala, India. He has over 60 publications that have been cited over 253 times, and his publication h-index is 8.