Shoebul HaqueKing George Medical University , India
Title: An experimental study to assess the memory-enhancing property of pitavastatin and gemfibrozil in mice using the Morris-water maze model. Evidence to categorize them as smart drugs
Introduction: Discovery of smart drugs is part of the advancement in the science of molecular and biochemical mechanisms of memory. Smart drugs are not just memory boosters, they also act as memory enhancers that help in quick decision-making. Pitavastatin, an HMG-CoA reductase inhibitor acts by decreasing serum cholesterol and triglycerides both by enhancing the upregulation of hepatocellular LDL-receptor expression. Gemfibrozil is causing a lipid-lowering effect by stimulating peroxisome proliferator-activated receptor alpha (PPAR?). Recent studies describe their pleiotropic effects apart from hypolipidemic. According to a few studies they can act on CREB (c-AMP response elemental binding protein), a known transcription factor. CREB performs an essential role in long-term memory restoration.
Aim and objectives: Present study was done to evaluate the memory enhancer effect of pitavastatin and gemfibrozil in Comparison to piracetam using Balb-c mice in the Morris-water maze behavioural model.
Material and methods: 24 balb/c mice were divided into 4 groups. The Morris-water maze was used to evaluate the memory-enhancer effect. The escape latency period and time spent in the target quadrant were compared among 4 groups. Observations were analyzed by using paired t-tests, ANOVA, and post hoc Tukey’s test.
Results: Pitavastatin (30mg/kg) and gemfibrozil (60mg/kg) makes significant decline in the escape latency period. pitavastatin, increased the total time spent in the target quadrant as compared to vehicle control in the Morris-water maze test (p< 0.01). However, gemfibrozil fails to show any increment in spending time in the target quadrant.
Conclusion: In the present study we concluded that both pitavastatin and gemfibrozil possess memory-enhancer properties and we can define them as “smart drugs”. However further studies are needed to confirm that hypothesis.
Shoebul Haque is working as resident in pharmacology and therapeutics department at King George Medical University, Lucknow. He received a bachelor’s degree in Medicine from Smolensk State Medical University Smolensk, Russia in 2012. A Post graduate diploma in Maternal and Child health care from IGNOU university in 2015, Delhi and a Post graduate diploma in infectious diseases from Medvarsity in 2016. He has served as an in-charge doctor of Mohalla clinic in Delhi Government and as a medical officer in Uttar-Pradesh government, India. His current field placement is in pharmacology department of KGMU where he is doing research on different effect of drugs on animals. It works under (CCSEA) The Committee for the Control and Supervision of Experiments on Animals