Introduction: Discovery of smart drugs is part of the advancement in the science of molecular and biochemical mechanisms of memory. Smart drugs are not just memory boosters, they also act as memory enhancers that help in quick decision-making. Pitavastatin, an HMG-CoA reductase inhibitor acts by decreasing serum cholesterol and triglycerides both by enhancing the upregulation of hepatocellular LDL-receptor expression. Gemfibrozil is causing a lipid-lowering effect by stimulating peroxisome proliferator-activated receptor alpha (PPAR?). Recent studies describe their pleiotropic effects apart from hypolipidemic. According to a few studies they can act on CREB (c-AMP response elemental binding protein), a known transcription factor. CREB performs an essential role in long-term memory restoration. 

Aim and objectives: Present study was done to evaluate the memory enhancer effect of pitavastatin and gemfibrozil in Comparison to piracetam using Balb-c mice in the Morris-water maze behavioural model.

Results: Pitavastatin (30mg/kg) and gemfibrozil (60mg/kg) makes significant decline in the escape latency period. pitavastatin, increased the total time spent in the target quadrant as compared to vehicle control in the Morris-water maze test (p< 0.01). However, gemfibrozil fails to show any increment in spending time in the target quadrant.