Skorodumova E.GI.I. Dzhanelidze Research Institute of Emergency Medicine, Russian Federation
Title: The relationship between multifocal atherosclerosis, gender and lipid profile parameters in patients with bronchogenic lung cancer
Background: Patients with atherosclerotic lesions of two or more pools or multifocal atherosclerosis (MFA), have risks of ischemic events are extremely higher than without atherosclerosis. MFA leads not only to the development of cardiovascular outcomes, but also to a decrease in the patient's quality of life. The prevalence of this pathology and the importance of preventing adverse outcomes are often underestimated, especially in the structure of the presence of oncological pathology, which initially increases the likelihood of thrombosis against the background of atherosclerosis.
Purpose: To assess the lipid profile and identify the features of the laboratory picture in patients with multifocal atherosclerosis.
Materials and methods: The study included 102 patients with angina pectoris (62 male (60.8%) and 40 female (39.2%), mean age 64.2±12.7 years, mean smoking history 40.2±3.4 years. 52 patients had proven multifocal atherosclerosis, which corresponded to the minimum threshold level of statistical significance p<0.05.
Results: The MFA scale was based on the Diamond-Forrester, Duke, CADC models for assessing the risk of coronary artery stenosis, as well as the SMART scale, since endpoint predictors should be associated with atherosclerosis, however, there was only statistical significance of such a relationship for total cholesterol (TC) (r=0.619; p<0.001), low-density lipoproteins (LDL) (r=0.686; p<0.001), gender (r=0.295; p=0.049). The atherogenic coefficient (CA), which is not included in these scales, had a fairly high correlation coefficient r=0.484 (p=0.048). The degree of interaction of factors and multifocal atherosclerosis was as follows. For TC, the influence of the factor on the development of multifocal atherosclerosis was 3.731 at p=0.040, while another point of view was 34.517 at p<0.001; thus, leading to a ratio of 1:9.25; the same pattern is typical for LDL - Factor ? MFA - 4.798 at p=0.032, while MFA ? factor 24.731 at p<0.001. The same pattern was observed for CA: 4.123 p=0.048 and 4.587 at p=0.023. The development of MFA with bronchogenic lung cancer had an effect 9.25 times higher on the level of TC in the blood, compared with the effect of total cholesterol on the development of multifocal atherosclerosis, the same is true for LDL (5.15 times). The level of CA had a interaction of 1:1.112. The level of high density lipoproteins did not affect the development of MFA (F=1.80, p=0.19). In patients with MFA, the male predominated (F=3.973, p=0.048). This model was tested using ROC analysis: the area under the curve was 0.798, which corresponded to a “good” score on the area under the curve scale.
1) Multifocal atherosclerosis in a patient with bronchogenic lung cancer is a factor that increases blood levels of TC (9.25:1) and LDL (5.15:1);
2) Male with bronchogenic lung cancer have a higher risk of development MFA than female (4.021:1).
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