Sonia JohriITM University, India
Title: Amelioration by T. aestivum and P. betel leaves against Phenyl Hydrazine Induced Anemia in Rats
Plants have been a source of vital pharmaceutical drugs for the treatment of many diseases. The present study aims to examine the antioxidant and antianemic potential of T. aestivum and P. betel extract. The FTIR and HPLC were performed for the characterization studies and revealed the presence of catechin (Flavonol) and many other flavonoids. Hematological and ferrokinetic parameters were performed using standard laboratory methods in haloperidol and phenylhydrazine induced anemia in rat model In phenylhydrazine induced anemia, twenty-five female albino ratsweighing 110 ± 10 g were divided into five groups of 5 animals each. The liver was excised for determination of Lipid Peroxidation (LPO), reduced glutathione (GSH) levels, Superoxide Dismutase (SOD), Catalase (CAT), Glutathione S-Transferase (GST), Glutathione Reductase (GR) glutathione peroxidase (GPx). Results revealed that TBARS levelis significantly increased in the phenyl hydrazine group and decreased in the treatment group. GSH, SOD, CAT, GST,GR and GST level is decreased in toxicant group and significantly increased in the therapy group. Results concluded that combination (TA+PB) therapy showed the best results in comparison to TA and PB therapy individually.
Sonia Johri presently working as Dean Academics in ITM University, Gwalior is a postgraduate in Biochemistry was awarded her doctoral degree in 2000 from Jiwaji University, Gwalior, M.P. Soon after her Ph.D, she pursued her post doctoral research sponsored by CSIR, New Delhi, India. She has research experience of almost 27 years and has worked extensively in the diversified fields of metal toxicity, anemia, hepatoprotection, oxidative stress and biofuels. She holds expertise in toxicological evaluation of metal toxicants and their therapy in rat model, phytomedicine, oxidative stress, physicochemical characterization of natural products as well as invitro and invivo biochemical characterization. She has also worked on bioethanol production from agro wastes. She has attended and presented her work in various international conferences held at Munich, Germany and Quebec City, Canada. She has around 45 papers and 3 books to her credit in journals of national and international repute. Her H index is 10. She is an external member, Board of studies in Biochemistry, Jiwaji University, Gwalior. She is also a member of Institutional Animal Ethical Committee, ITM University, Gwalior. She has the credit of being a reviewer in various national and international journals.