Virtual Conference

Syatirah Jalaluddin

UIN Alauddin Makassar, Indonesia

Title: Effect of bitter bush cream (Chromolaena odorata L.) on metalloproteinase-1 expression


MMP-1 is one of several matrix metalloproteinases (MMPs or collagenases) that can be increased by UV light on human skin. MMP-1, also known as fibroblast collagenase, is the major protease enzyme responsible for the breakdown of extracellular matrix components in the dermis, which results in collagen degradation and photoaging. By using immunohistochemistry methods in BALB/c mice exposed to 500 mJ/cm2 UVB rays, this study sought to assess the effect of Bitter Bush cream on MMP-1 expression. There were 24 mice in all, divided into four groups: I (normal control without treatment), II (placebo cream and UVB), III (UVB), and IV (1% Bitter Bush cream). All of the experimental animals were slaughtered, and cervical dislocation was accomplished using an excisional biopsy of the back skin for MMP-1 analysis. According to the results of the MMP-1 expression test, there were discrepancies in MMP-1 expression between groups I, II, III, and IV. The Kruskal-Wallis test revealed significant differences between groups with p<0.05. The Mann-Whitney U post hoc test revealed that the expression of MMP-1 in group I was significantly different from group II and group III, with with p<0.05, and that there was no significant difference between groups I and IV, with p>0.05. MMP-1 expression is inhibited by Bitter Bush cream.


Syatirah Jalaluddin has completed her PHD at the age of 38 years from Universitas Hasanuddin, Makassar, Indonesia. She is a lecturer and Dean of Faculty of Medicine and Health Science, UIN Alauddin Makassar,Indonesia. She has over ten publications and one book that have been cited over 10 times, and her publication h-index is 2.