Vaishali RaghuwanshiSri Aurobindo Institute of Pharmacy, India
Title: Development and optimization of eletriptan hydrobromide sublingual tablet using central composite design and in-vitro characterization
In the present investigation, sublingual tablets were prepared using solid dispersion by physical mixture method having β- Cyclodextrin as solubility enhancer and sodium starch glycolate as super disintegrant, which gives rapid onset of action. By using the direct compression technique to prepare the tablet formulation. A central composite design was composed in which the amount of sodium starch glycolate (X1) and PVP K-30 (X2) were chosen as the independent variables and the dependent variables were disintegration time (Y1) in seconds and In- vitro % drug release (Y2) in percentage. Various parameters i.e., hardness, friability, thickness, weight variation, wetting time, and water absorption ratio were determined for the prepared tablets. It was observed that the SLT4 formulation shows a disintegration time of 60 sec. and in- vitro % drug release with 96.36% shown in 15 minutes, which shows that the sublingual route can be the option for the administration of Eletriptan hydrobromide.
Vaishali Raghuwanshi has completed her master's at the age of 22 years from AIPER, Indore. She is a member of Association of Pharmaceutical Teachers of India (APTI). Currently working as Assistant Professor at Sri Aurobindo Institute of Pharmacy, Indore. Worked in NAAC, website, social media, NPTEL committee, Skill India trainer, and member of Institution’s Innovation Council (IIC). Awarded Merit for Chancellor’s Scholarship from University (RGPV), Bhopal in her bachelor’s (2019- 2020). She participated in the 72nd Indian Pharmaceutical Congress (IPC) held at Pharmaceutical Sciences, Rashtrasant Tukadoji Nagpur University.