Vaishali ShahVIVA Institute of Pharmacy, India
Title: Development and evaluation of polyherbal formulation for urolithiasis
Urolithiasis, one of the most painful ailments of the urinary tract disorder, has beset humans from centuries. Medical treatments for kidney stone are relatively costly, painful and require expert hands and availability of appropriate equipments. So, the present research work had been undertaken for the Development and evaluation of polyherbal formulation for kidney stone. The formulation was developed using powders of Tribulus terrestris, Crataeva nurvala, Kalanchoe pinnata which are individually well reported in Ayurveda for Urolithiassis. Morphological, microscopical study and physicochemical parameters of all the plants present in formulations were done to identify the plants. The phytochemical screening was performed for presence of phytoconstituents. Total phenolic & total flavanoids content were calculated by Folin ciocalteau method and AlCl¬3 colorimetric method. Antioxidant activity was done by DPPH assay, Superoxide free radical scavenging activity & Reducing power assay. Anti-lithiatic acivity was performed by In vitro model- homogenous precipitation method. Phytochemical screening of formulation showed the presence of alkaloids, tannins, saponins, flavonoid. Total phenol and flavonoid content was 0.53 % and 0.51 % w/w respectively. It showed significant in vitro antioxidant activity in dose dependent manner as evident by antioxidant assay. Anti-lithiatic activity was performed which shows that the formulation has good anti-lithiatic activity and supports its tradional uses for kidney stone and showed synergistic effect in combination.
Vaishali Shah has completed his PHD at the age of 33 years from Gujarat University, India. She is the Associate professor at VIVA institute of Pharmacy Virar Mumbai since 2017, India. She has 26 publications and 7 Presentation in her research credit. She has guided 34 PG students She has also received minor research grant from Mumbai university and travel grant from AICTE. She is life member of APTI Association of Pharmacy teachers of India and ISP (Indian Society of Pharmacognosy