Victor KostenkoSt-Petersburg Research Institute for Emergency Care, Russian Federation
Title: Exogenous molecular pattern in patients with decompensated heart failure and intermediate left ventricle ejection fraction
The purpose was to determine the relationship of latent infections with course of chronic heart failure (CHF) on the basis of cross-analysis of correlation between infectious antigens and antibodies in patients with intermediate left ventricular function. Material and methods. Exogenous molecular pattern, included phagocytic indices of 30% and 60%, phagocytic numbers for 30 and 60 minutes, phagocytosis completion index, lipopolysaccharide of gram-negative bacteria wall, antistreptolysin-O, interleukin-6, immunoglobulins M and G to Ebstein-Barr virus, cytomegalovirus, Candida and Aspergillus fungi, Toxoplasma gondi, Mycoplasma gondi, Mycoplasma pneumonia, were studied in 195 patients with CHF and intermediate left ventricle`s function after relief of heart failure`s decompensation. The average age of patients was 65.2 ± 3.6 years. 64.3 % of them were males, 25.7 % - females. Results. Cross-analysis between infectious antigens and antibodies in patients with intermediate function of the left ventricle, and complicated course of disease revealed that patients with heart failure decompensation and intermediate function of the left ventricle had latent infection with a large number of bacterial, viral and fungal agents, as well as intracellular parasites, leading to the development of persisting systemic inflammatory reaction. Main strong correlations were established for Streptococcus aureus (0,741, p=0,007), Cytomegalovirus (0,889, p=0,001), Epstein-Barr virus (0,889, p=0,001), Lipopolysaccarids (p<0,001), Mycoplasma (p=0,011), Toxoplasma (p=0,015). Conclusion.The results of this study allow us to determine several antibodies to pathogens in clinical practice without using entire diagnostic panel in heart failure decompensation, as Streptococcus aureus, Cytomegalovirus, Epstein-Barr virus, Lipopolysaccarids, Mycoplasma, Toxoplasma.
Victor Kostenko has completed his PHD at the age of 37 years from St-Petersburg Research Institute for Emergency Care, Russia. He is the head of Urgent Cardiology and Rheumatology Department of St-Petersburg Research Institute for Emergency Care, Russia. He has over 220 publications that have been cited over 5500 times, and his publication h-index is 17. He has been involved in up to 150 international clinical studies as Investigator and safety board member.