Yuri V. NesvizhskySechenov University , Russian Federation
Title: The association between Candida albicans sensitivity to antimycotic drugs and the architecture of their microbial community in the oropharynx of HIV infected patients
Candida infection remains relevant due to the wide spread of antimycotic-resistant strains of Candida fungi, especially among immunocompromised individuals. It was previously discovered that the Candida spp microbial community in the biotope of the oropharynx of HIV-infected patients is characterized by a certain architecture: they can be present in this biotope in the form of a monoculture or an association of co-isolates. It has been suggested that the architecture of the Candide community may influence their resistance to antimycotic drugs. A comparative study of the relationship between the architecture of the C.albicans community in the oropharynx of HIV-infected patients with oropharyngeal candidiasis and their sensitivity to antimycotic drugs. A microbiological study of 52 isolates of Candida fungi (C.albicans, C.glabrata, C.tropicalis and C.krusei) from the oropharynx of 31 HIV-infected patients with clinical manifestations of oropharyngeal candidiasis aged 20 to 69 years with almost equal gender distribution was carried out. In the form of monocultures, 18 isolates were isolated, as well as 34 co-isolates, which formed 16 homogeneous associations, including strains of only one species, and 18 heterogeneous ones, consisting of fungi of various species. It was found that heterogeneous associates of C.albicans were markedly distinguished by sensitivity to antimycotic drugs, in particular, low sensitivity to imidazoles. Homogeneous associants practically did not differ from monocultural ones. The general properties of the C. non-albicans population were largely similar to those of C.albicans, but were characterized by lower heterogeneity in response to antimycotic drugs. The architecture of the community of C. albicans isolated from the oropharynx of HIV-infected patients with clinical manifestations of oropharyngeal candidiasis affects their sensitivity to antimycotic drugs. When selecting effective antimycotic therapy for such patients, it is necessary to consider the structure of the Candida spp community. in the oropharynx.
Yuri V. Nesvizhsky is a PhD, Doctor of Medical Science, Professor. He has extensive experience in research in the field of microbiology and immunology, as well as teaching these disciplines at the university. He has over 230 publications that have been cited over 2600 times? Including 108 articles in peer-reviewed journals, as well as several patents and manuals. He supervised the research of 10 PhDs in the field of immunology and microbiology. He has been serving as a member of editorial board of several reputed journals and scientific councils.